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Dr John Carr

Abstract:

The research group works on defensive signal transduction in plants; how it can be effective in protecting plants against pathogens and how, sometimes, defensive signaling is re-program by the pathogens to serve their nefarious interests.  Research is focused on two main areas:    1. How the ‘classical’ defensive systems regulated by salicylic acid and jasmonic acid work in concert with defense based on RNA silencing   and  2. How viral suppressors of RNA silencing and other viral gene products manipulate the interactions of plant hosts with other organisms- especially those that transmit viruses.       Projects offer training in a wide range of techniques including molecular biology, cell biology, molecular virology, physiological investigations of insect behavior, and analysis of biologically active metabolites by HPLC and GC.    John Carr is happy to meet prospective students to discuss projects in detail.

References:

  1. Westwood, JH, Groen, SC, Du, Z, Tungadi, T, Lewsey, MG, Luang-In, V, Murphy, AM, Rossiter, J, Powell, G, Smith, AG, Carr, JP (2013). A trio of viral proteins tunes aphid-plant interactions in Arabidopsis thaliana.  PLoS ONE 8(12): e83066. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0083066    
  2. Westwood, J.H., Lewsey, M.G., Murphy, A.M., Tungadi, T., Bates, A., Gilligan, C.A. and Carr, J.P. (2014) Interference with jasmonic acid- regulated gene expression is a general property of viral suppressors of RNA silencing but only partly explains virus-induced changes in plant-aphid interactions. Journal of General Virology http://vir.sgmjournals.org/content/early/2013/12/20/vir.0.060624-0.abstract    
  3. Du, Z., Chen, A., Chen, W., Westwood, J.H., Baulcombe, D.C., Carr, J.P. (2014). Using a viral vector to reveal the role of miR159 in disease symptom induction by a severe strain of cucumber mosaic virus. Plant Physiology In Press

Dr John Carr

Dr John Carr
Department of Plant Sciences
Office Phone: 01223 766416

Second supervisor:

Various