Basic bioscience is vital to reveal the biological mechanisms underlying normal physiology and homeostatic control during early development and through life, and is one of the BBSRC’s strategic research priorities. Research in this theme aims to achieve a deep, integrated understanding of the healthy system at multiple levels and the factors maintaining health under stress and biological or environmental challenge. A wide variety of projects are offered encompassing basic bioscience research topics where the goal is to help sustain lifelong health and wellbeing - through prevention strategies or new treatments - in the modern environment.
Projects range from structural biology to experimental psychology, as well as those with multidisciplinary or systems approaches. Specific topics include studies on protein folding, chromosome structure and stability, gene regulation and epigenetics, DNA replication and repair, cell division mechanisms and cell cycle control, cell signalling networks, homeostasis, stem cells, development, the processes of cell growth, degeneration and regeneration, apoptosis, neuronal growth and plasticity, the processes of ageing and longevity, host-pathogen interactions, disease transmission, antibiotic resistance, vaccines, metabolic biology and the genetics/physiology/psychology of obesity, processes of learning/attention and decision making, genetic variation and evolutionary adaptation, and the development and use of new tools in areas such as structural analysis, bioimaging, high throughput and comparative genomics and modelling. Projects encompassing biophysical, materials chemistry and engineering approaches are also available.
Examples of the types of projects in the Bioscience for Health theme from previous years can be viewed here.