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Dr Simon Frost

Abstract:

This computational biology project will involve exploring how recombination shapes the evolution of (a) viruses and/or (b) immunoglobulins, to help understand how viruses and antiviral antibody-mediated immunity co-evolve. The student will explore how to characterise and visualise recombination, with a view to developing new techniques; as such, s/he should be highly computer literate.

References:

  1. Simon DW Frost, Terri Wrin, Davey M Smith, Sergei L Kosakovsky Pond, Yang Liu, Ellen Paxinos, Colombe Chappey, Justin Galovich, Jeff Beauchaine, Christos J Petropoulos, Susan J Little, Douglas D Richman  Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection  PNAS 102:18514-18519 (2005)   
  2. Sergei L Kosakovsky Pond, David Posada, Eric Stawiski, Colombe Chappey, Art FY Poon, Gareth Hughes, Esther Fearnhill, Mike B Gravenor, Andrew J Leigh Brown, Simon DW Frost  An evolutionary model-based algorithm for accurate phylogenetic breakpoint mapping and subtype prediction in HIV-1  PLoS Comp Biol  5:e1000581 (2009)  
  3. Simon DW Frost, Erik M Volz  Modelling tree shape and structure in viral phylodynamics  Phil Trans Roy Soc B 368:20120208 - 20120208 (2013)

Dr Simon Frost

Dr Simon Frost
Department of Veterinary Medicine
Office Phone: 01223 764201