My lab focuses on dopaminergic neurons of the substantia nigra, and in particular glutamatergic synapses and the NMDA type of glutamate receptors found in dopamine neurons. We use electrophysiological approaches to study the properties and regulation of NMDA receptors by extracellular and intracellular molecules. We hope that our work will shed new light on specific mechanisms regulating cell survival and cell death that might be important in neurodegenerative disease. We also aim to better understand the properties of NMDARs, which are ubiquitous in the mammalian brain and play important roles in neuronal development, survival and plasticity.
- A.R. Wild, S. Jones and A.J. Gibb (2014). Activity dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones. J Physiology In Press
- A.R. Wild, E. Akyol, S.L.C. Brothwell, P. Kimkool, J.N. Skepper, A.J. Gibb and S. Jones (2013). Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones. Neuropharmacology 73:138-146
- SLC Brothwell, JL Barber, DT Monaghan, DE Jane, AJ Gibb & S Jones (2008). NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. Journal of Physiology 586, 739-750.