DEPARTMENT/LOCATION: Department of Biochemistry, Central Cambridge
CLOSING DATE: 31 March 2015
A BBSRC PhD studentship fully funded for four years is available in the laboratory of Professor Paul Dupree. The project is in partnership with Novozymes, the world's largest enzyme discovery and production company.
The industrial collaborative project aims to develop tools and understanding with application to the bioenergy, biorefining and dietary uses of plants. The project goal is to understand tthe role of the plant cell wall polysaccharide xylan in preventing enzymatic digestion of cellulose microfibrils. Our recent discoveries propose new models for xylan interaction with cellulose (Busse Wicher et al. 2014). The new models suggest new types of enzymes may be involved in plant cell wall deconstruction.
The project will use the extensive range of specific recombinant hydrolases and polysaccharide oxidases (e.g. cellulases, xylanases, LPMOs) available from Novozymes, and also the extensive panel of plants with modified plant cell wall synthesis available in the laboratory of Paul Dupree.
The student will spend at least three months in Novozymes, Copenhagen, gaining experience of industrial enzyme discovery and development.
The project will start during the 2015-2016 academic year.
Busse-Wicher M et al. (2014) The pattern of xylan acetylation suggests xylan may interact with cellulose microfibrils as a two-fold helical screw in the secondary plant cell wall of Arabidopsis thaliana. Plant J. 79(3):492-506.
Enquiries to Paul Dupree email@example.com. See also http://www.bioenergy.novozymes.com
BBSRC studentship eligibility conditions apply: EU applicants will receive funding for fees. Home and EU applicants recently resident in the UK will receive fees and maintenance. See the BBSRC studentship web site for details:
Please quote reference PH04924 on your application and in any correspondence about this vacancy.
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