The Cambridge BBSRC DTP Partnership would like to congratulate Laura-Nadine Schuhmacher who recently published a paper entitled: 'Structural Domains Underlying the Activation of Acid-Sensing Ion Channel 2a', in Molecular Pharmacology.
This paper aims to characterise the functional domains of acid-sensing ion channels (ASICs), membrane proteins expressed in nociceptors that are permeable to ions and can elicit action potentials, whose activation plays an important role in pain signalling, for example in inflammation or arthritis. Chimeras of functional (ASIC2a) and non-functional (ASIC2b) proteins were created and investigated using whole-cell patch-clamp electrophysiology in order to narrow down the minimal sequence that is necessary for acid sensing and channel opening. Further details can be found here - http://molpharm.aspetjournals.org/content/87/4/561.full
Laura-Nadine is in her third year as a BBSRC DTP student, currently carrying out her PhD with Dr Ewan St John Smith in the Department of Pharmacology.