Alex Fulton
- PhD Student
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MRC Toxicology Unit
Research theme: Bioscience for an integrated understanding of health
Research
Project Title:
Investigating off-target toxicity in RNA therapeutics
Project Summary:
Antisense oligonucleotides (ASOs) are a relatively new form of RNA therapeutic which have had recent success in clinical trials and gained medical approval. However, little is still known about the toxicity of these drugs, especially in the liver and kidney where toxicity biomarkers are commonly elevated, which can lead to severe adverse reactions.
Professor Anne Willis OBE