Project Title:

Investigating Bacteriophage – Host Interactions in Clinical Isolates of Pseudomonas aeruginosa

Project Summary:

The growing threat of multi-drug resistant bacteria has meant that the interest in phage therapy as an alternative to antibiotics has likewise been growing. This approach is however heavily limited by our understanding of the bacterial infections and bacteriophages involved. The project aims to interrogate clinical samples of P. aeruginosa for properties predicting pathology and susceptibility. Bacteriophages have been isolated against them, and investigated for key characteristics impacting phage-host interactions, such as host range, life cycle, carriage of virulence factors, and generalised transduction.