skip to primary navigationskip to content

Congratulations to Claudia Pama on her publication in Developmental Neurobiology

last modified Nov 30, 2017 02:22 PM

Congratulations to Claudia Pama, 2014 cohort PhD student in the BBSRC DTP Programme, for publishing the review article Neuroglial interactions underpinning myelin plasticity in Developmental Neurobiology. 



The CNS is extremely responsive to an ever-changing environment. Studies of neural circuit plasticity focus almost exclusively on functional and structural changes of neuronal synapses. In recent years, however, myelin plasticity has emerged as a potential modulator of neuronal networks. Myelination of previously unmyelinated axons and changes in the structure of myelin on already-myelinated axons (similar to changes in internode number and length or myelin thickness or geometry of the nodal area) can in theory have significant effects on the function of neuronal networks. In this article, the authors review the current evidence for myelin changes occurring in the adult CNS, highlight some potential underlying mechanisms of how neuronal activity may regulate myelin changes, and explore the similarities between neuronal and myelin plasticity.

Link to paper.


Claudia is researching activity dependency of myelination in the lab of Dr Ragnhildur Thora Karadottir at the Cambridge Stem Cell Institute. As part of the BBSRC DTP Programme she completed rotation projects in the Stem Cell Institute/Veterinary Medicine and in the Department of Psychology with Professor Trevor Robbins.