Project Title:

Elucidating the effects of dietary change on ageing in Saccharomyces cerevisiae

Project Summary:

Dietary restriction is a well-established method in increasing the lifespan of a wide range of organisms. However, a longer lifespan often comes at a cost of declining health due to ageing. Previous work conducted on Saccharomyces cerevisiae (baker’s yeast) showed that simple diet change to different carbon sources, rather than just dietary restriction alone, can have a positive effect on ageing health. The underlying molecular and genetic mechanisms of these dietary effects are not well known. During my work, by examining different markers of ageing and gene expression changes in the yeast, some of these mechanisms have unrevealed themselves.