Department of Chemistry
Research theme: Understanding the rules of life
Biography
I’m a Nigerian born British who grow up in Croydon. I completed my undergraduate studies in Biochemistry at Kingston University where I investigated the inhibitory effect of polyphenols on the activity of acetylcholinesterase extracted from mice brain, after that I undertook a Masters of research programme in Biosciences at UCL where I looked at the impact of nutrients, small molecules and microbes in the regulation of host health through the employment of model organism, C. elegans. Before embarking on my PhD I worked as a research assistant at Imperial college London whilst demonstrating and teaching a molecular biology practical course at New York University.
Research
Project Title:
Phase separation of Alpha-synuclein
Project Summary:
Investigating protein misfolding in neurodegenerative diseases. More specifically, I am studying the mechanisms and kinetics of alpha synuclein aggregation through Liquid-liquid phase separation (the partitioning of a heterogeneous solution into two phases, a dense/concentrated phase and a dilute phase) as we believe this could be a physiological pathway in which this protein aggregates to potentially form neurotoxic oligomers and insoluble fibrils that are constituents of Lewy bodies which are the pathological hallmark of Parkinson’s disease.
Publications
Teaching and Supervisions
Professor Michele Vendruscolo
