Tracking the entirety of developmental exposures and their impact on the mammalian epigenome
Project Summary:
Through utilising a series of novel reporter lines, I am investigating the impact of selected drug exposures during pregnancy and tracking the longitudinal nature of responses. I am particularly interested in exploring the effects of environmental and pharmacological toxic insults on the developing epigenome and imprinted loci.
Ferreira ACF, Szeto ACH, Heycock MWD, Clark PA, Walker JA, Crisp A, Barlow JL, Kitching S, Lim A, Gogoi M, Berks R, Daly M, Jolin HE, McKenzie ANJ. RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus. Nat Immunol. 2021 Feb;22(2):166-178. doi: 10.1038/s41590-020-00833-w. Epub 2021 Jan 11. PMID: 33432227; PMCID: PMC7116838.
