Natalie attended the Institute of Metabolic Science (IMS) Away Day at Robinson College where she presented a poster of her PhD research. Natalie’s research focuses on elucidating the genetic basis of obesity and how investigation in dogs can offer translational insight into human obesity.

The IMS research retreat focused on the research of human metabolic diseases including obesity, cachexia, and diabetes, among others. The majority of the posters were focused on human and mice studies, apart from Natalie’s. Natalie has undertaken a genetic study in a cohort of Labrador retrievers to investigate the genetic basis of adiposity in this obesity-prone dog breed. Genome wide association studies coupled with selective sweep mapping, human comparative genomics and polygenic risk scoring, meant for a compelling research story.

 

The posters were viewed and assessed in several sessions throughout the research retreat. Although it was the only dog-related poster at the event, this niche model animal seemed to interest people and Natalie hopes that the use of non-traditional animal models in metabolic disease research is now further appreciated. Natalie was awarded a best poster prize by head of department Sir Professor Stephen O’Rahilly.